Adm1n: Created page with "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid recept..."

2015-02-17T03:58:16Z

Created page with "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid recept..."

New page

AM-251 is an inverse agonist at the [[CB1]] cannabinoid receptor. AM-251 is structurally very close to SR141716A ([[rimonabant]]); both are biarylpyrazole [[cannabinoid receptor antagonist]]s. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the [[CB1]] receptor (with a Ki value of 7.5nM) than SR141716A, which has a Ki value of 11.5nM, AM-251 is, however, about two-fold more selective for the CB1 receptor when compared to SR141716A.

==See also==

* [[ Cannabinoid receptor antagonist]]

AM-251 - Revision history

Adm1n: Created page with "AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid recept..."