Adm1n: Created page with "AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. Other cannabinoid anta..."

2015-02-16T15:06:13Z

Created page with "AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. Other cannabinoid anta..."

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AM-6545 is a drug which acts as a peripherally selective silent antagonist for the [[CB1]] receptor, and was developed for the treatment of obesity. Other [[cannabinoid]] antagonists such as [[rimonabant]] have been marketed for this application, but have subsequently been withdrawn from sale because of centrally mediated side effects such as depression and nausea. Because AM-6545 does not cross the blood–brain barrier to any significant extent, it does not produce these kinds of side effects, but has still been shown to effectively reduce appetite and food consumption in animal studies.

==See also==

* [[CB-13]] – a peripherally selective cannabinoid agonist

* [[O-2050]] – a centrally active CB<sub>1</sub> silent antagonist

* [[TM-38837]] - another peripherally selective cannabinoid antagonist

AM-6545 - Revision history

Adm1n: Created page with "AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. Other cannabinoid anta..."