Adm1n at 11:11, 14 April 2015

2015-04-14T11:11:36Z

Adm1n: Created page with "'''CP 55,940''' is a cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in cannabis). CP 55,940 was created b..."

2015-04-14T11:11:05Z

Created page with "'''CP 55,940''' is a cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in cannabis). CP 55,940 was created b..."

New page

'''CP 55,940''' is a [[cannabinoid]] which mimics the effects of naturally occurring [[THC]] (one of the psychoactive compounds found in [[cannabis]]). CP 55,940 was created by Pfizer in 1974 but was never marketed. It is currently used to study the[[ endocannabinoid]] system. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice,[citation needed] and a greater reaction to opiates in exposed mice.

A study found that CP 55,940 can upregulate 5-HT2A receptors in mice.

CP 55,940 is 45 times more potent than Δ9-[[THC]], and fully antagonized by [[rimonabant]] (SR141716A).

CP 55,940 is considered a full agonist at both [[CB1]] and [[CB2]] receptors and has Ki values of 0.58nM and 0.68nM respectively, but is an antagonist at [[GPR55]], the putative "CB3" receptor.

CP 55,940 showed protective effects on rat brain mitochondria upon paraquat exposure.

It also showed neuroprotective effects by reducing intracellular calcium release and reducing hippocampal cell death in cultured neurons subjected to high levels of NMDA.

CP 55,940 induced cell death in NG 108-15 Mouse neuroblastoma x Rat glioma hybrid brain cancer (genetically engineered mouse x rat brain cancer) cells.

== See also ==

*[[CP 47,497]]

← Older revision		Revision as of 11:11, 14 April 2015
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−	CP 55,940 is considered a full agonist at both [[CB1]] and [[CB2]] receptors and has Ki values of 0.58nM and 0.68nM respectively, but is an antagonist at [[GPR55]], the putative "CB3" receptor.	+	CP 55,940 is considered a full agonist at both [[CB1]] and [[CB2]] receptors and has Ki values of 0.58nM and 0.68nM respectively, but is an antagonist at GPR55, the putative "CB3" receptor.

CP 55,940 - Revision history

Adm1n at 11:11, 14 April 2015

Adm1n: Created page with "'''CP 55,940''' is a cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in cannabis). CP 55,940 was created b..."