JWH-098 - Revision history

Adm1n at 14:16, 16 February 2015

2015-02-16T14:16:53Z

Adm1n at 14:03, 16 February 2015

2015-02-16T14:03:49Z

Adm1n: Created page with "JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but ha..."

2015-02-16T14:02:43Z

Created page with "JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but ha..."

New page

JWH-098 is a synthetic [[cannabinoid receptor]] agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound [[JWH-081]], but has markedly different affinity for the [[CB1]] and [[CB2 receptor]]s. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.

==See also==

* [[JWH-007]]

* [[JWH-081]]

← Older revision		Revision as of 14:16, 16 February 2015
Line 1:		Line 1:
−	JWH-098 is a synthetic [[cannabinoid receptor ~~agonist~~]] from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound [[JWH-081]], but has markedly different affinity for the [[CB1]] and [[CB2 receptor]]s. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.	+	JWH-098 is a synthetic [[cannabinoid receptor]] agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound [[JWH-081]], but has markedly different affinity for the [[CB1]] and [[CB2 receptor]]s. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.

	==See also==		==See also==

← Older revision		Revision as of 14:03, 16 February 2015
Line 1:		Line 1:
−	JWH-098 is a synthetic [[cannabinoid receptor]] ~~agonist~~ from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound [[JWH-081]], but has markedly different affinity for the [[CB1]] and [[CB2 receptor]]s. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.	+	JWH-098 is a synthetic [[cannabinoid receptor agonist]] from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound [[JWH-081]], but has markedly different affinity for the [[CB1]] and [[CB2 receptor]]s. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.

	==See also==		==See also==