Adm1n: Created page with "'''JWH-424''' is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, but with moderate selectivity for C..."

2015-02-15T12:32:10Z

Created page with "'''JWH-424''' is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, but with moderate selectivity for C..."

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'''JWH-424''' is a drug from the naphthoylindole family, which acts as a [[cannabinoid]] agonist at both the[[ CB1]] and [[CB2 receptor]]s, but with moderate selectivity for CB2, having a Ki of 5.44nM at CB2 vs 20.9nM at CB1. The heavier 8-iodo analogue is even more CB2 selective, with its 2-methyl derivative having 40x selectivity for CB2. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall.

==See also==

* [[JWH-018]]

* [[JWH-398]]

JWH-424 - Revision history

Adm1n: Created page with "'''JWH-424''' is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, but with moderate selectivity for C..."