Adm1n at 10:59, 15 February 2015

2015-02-15T10:59:11Z

Adm1n: Created page with "KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol (THC), the less active but more stable isomer of the active component of Cannabis. km-233 differs fro..."

2015-02-15T10:58:32Z

Created page with "KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol (THC), the less active but more stable isomer of the active component of Cannabis. km-233 differs fro..."

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KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol ([[THC]]), the less active but more stable isomer of the active component of [[Cannabis]]. km-233 differs from Δ8-THC by the pentyl side chain being replaced by a 1,1-dimethylbenzyl group. It has high binding affinity in vitro for both the [[CB1]] and [[CB2 receptor]]s, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal studies it has been found to be effective for the treatment of glioma, a form of brain tumor. A large number of related analogues are known where the 1,1-dimethylbenzyl group is substituted or replaced by other groups, with a fairly well established structure-activity relationship.

== See also ==

* [[AM-411]]
* [[AMG-36]]

← Older revision		Revision as of 10:59, 15 February 2015
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−	KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol ([[THC]]), the less active but more stable isomer of the active component of [[Cannabis]]. km-233 differs from Δ8-THC by the pentyl side chain being replaced by a 1,1-dimethylbenzyl group. It has high binding affinity in vitro for both the [[CB1]] and [[CB2 receptor]]s, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal studies it has been found to be effective for the treatment of glioma, a form of brain tumor. A large number of related analogues are known where the 1,1-dimethylbenzyl group is substituted or replaced by other groups, with a fairly well established structure-activity relationship.	+	'''KM-233''' is a drug which is an analogue of Δ8-tetrahydrocannabinol ([[THC]]), the less active but more stable isomer of the active component of [[Cannabis]]. km-233 differs from Δ8-THC by the pentyl side chain being replaced by a 1,1-dimethylbenzyl group. It has high binding affinity in vitro for both the [[CB1]] and [[CB2 receptor]]s, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal studies it has been found to be effective for the treatment of glioma, a form of brain tumor. A large number of related analogues are known where the 1,1-dimethylbenzyl group is substituted or replaced by other groups, with a fairly well established structure-activity relationship.

	== See also ==		== See also ==

KM-233 - Revision history

Adm1n at 10:59, 15 February 2015

Adm1n: Created page with "KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol (THC), the less active but more stable isomer of the active component of Cannabis. km-233 differs fro..."