ADB-FUBINACA is a designer drug identified in synthetic cannabis blends in Japan in 2013. The (S) enantiomer of ADB-FUBINACA is claimed in Pfizer patent WO 2009/106982, with a Ki value of 0.36nM at CB1. ADB-FUBINACA features a carboxamide group at the 3-indazole position, like SDB-001 andSTS-135. ADB-FUBINACA appears to be the product of rational drug design, since it differs from AB-FUBINACA only by the replacement of the isopropyl group with a tert-butyl group. The stereochemistry of the tert-butyl side-chain in the illicitly sold product is unresolved. Nothing is known of the pharmacological activity of ADB-FUBINACA in humans or other animals.