Difference between revisions of "JWH-176"
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| − | JWH-176 is an analgesic drug which acts as a [[cannabinoid receptor]] agonist. Its binding affinity at the [[CB1]] receptor is only 26.0nM, making it more potent than [[THC]] itself, however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity [[cannabinoid]] binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor. It was discovered by, and named after, Dr. [[John W. Huffman]]. | + | JWH-176 is an analgesic drug which acts as a [[cannabinoid receptor ]]agonist. Its binding affinity at the [[CB1]] receptor is only 26.0nM, making it more potent than [[THC]] itself, however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity [[cannabinoid]] binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor. It was discovered by, and named after, Dr. [[John W. Huffman]]. |
==See also== | ==See also== | ||
* [[JWH-175]] | * [[JWH-175]] | ||
Latest revision as of 07:49, 16 February 2015
JWH-176 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 26.0nM, making it more potent than THC itself, however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor. It was discovered by, and named after, Dr. John W. Huffman.
