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Create the page "CB1 receptors" on this wiki! See also the search results found.

• JWH-015
  ...in some model systems can be very potent and efficacious at activating CB1 receptors, and therefore it is not as selective as newer drugs such as [[JWH-133]]. I
  1 KB (202 words) - 03:48, 15 February 2015
• JWH-133
  ...st, with a Ki of 3.4nM and selectivity of around 200x for CB2 over [[CB1]] receptors. It was discovered by, and named after, John W. Huffman. ...antiinflamatory action is induced through agonist action at [[cannabinoid receptors]], which prevents microglial activation that elicits the inflammation. Addi
  1 KB (214 words) - 03:51, 15 February 2015
• KM-233
  ...B2 receptor]]s, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal studies it has been found to be effective for the treat
  752 B (118 words) - 03:59, 15 February 2015
• AB-005
  ...e it was reported to have high affinity for both CB1 (Ki = 5.5 nM) and CB2 receptors (Ki = 0.48 nM).[1] AB-005 features groups found in other previously reporte
  1 KB (141 words) - 04:01, 15 February 2015
• JWH-250
  ...]] agonist at both the [[CB1]] and [[CB2 receptor]]s, with a Ki of 11nM at CB1 and 33nM at CB2. Unlike many of the older JWH series compounds, this compou
  1 KB (180 words) - 04:15, 15 February 2015
• SDB-006
  ...ors]], with an EC50 for [[CB1]] activation of 19nM, and 7x selectivity for CB1 over [[CB2]]. It was discovered during research into the related compound [
  353 B (53 words) - 04:27, 15 February 2015
• Cannabinoid receptor type 2
  ...its similarity in amino-acid sequence to the cannabinoid receptor type 1 (CB1) receptor, discovered in 1990. The discovery of this receptor helped provid ...uman CB2 receptor, making it somewhat shorter than the 473-amino-acid-long CB1 receptor.
  11 KB (1,520 words) - 12:12, 23 February 2015
• Cannabis and memory
  == Cannabinoid receptors == ...noid receptor]] research. With the discovery of the endogenous cannabinoid receptors, some recent scientific literature has focused on the effects of phytocanna
  24 KB (3,496 words) - 12:15, 23 February 2015
• Medical cannabis
  ...chers began to study and better understand how cannabinoids acted on these receptors. THC is associated – more than any other cannabinoid – with most of the ...ent of medical cannabis; it is a nonpsychotropic and how it works on brain receptors is not known. CBD represents up to 40% of extracts of Cannabis sativa. A 20
  26 KB (3,891 words) - 14:16, 23 February 2015
• HHC
  ...as later work using more complex compounds such as CP 55,244 to map the [[CB1]] binding site in more detail, but aside from these specific applications,
  2 KB (230 words) - 04:23, 13 February 2015
• HU-243
  ...e [[CB1]] and [[CB2]] receptors, with a binding affinity of 0.041nM at the CB1 receptor, making it marginally more potent than HU-210, which had an affini
  435 B (67 words) - 04:26, 13 February 2015
• Canbisol
  ...nding studies to determine the structure and function of the [[cannabinoid receptors]], but has been made illegal in some countries due to its possible abuse po
  580 B (84 words) - 04:29, 13 February 2015
• HU-210
  ...al stem and progenitor cells likely via a sequential activation of [[CB1]] receptors, Gi/o proteins, and ERK signaling. It was also indicated by this increased ...nti-inflammatory action is induced through the activation of [[cannabinoid receptors]], which prevents microglial activation that elicits the inflammation. In a
  2 KB (328 words) - 06:29, 14 February 2015
• JWH-018
  ...that acts as a full agonist at both the [[CB1]] and [[CB2]] [[cannabinoid receptors]], with some selectivity for CB2. It produces effects in animals similar to ...annabinoid (CB1) receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural det
  9 KB (1,244 words) - 06:53, 14 February 2015
• AM-630
  ...be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of a large number of related derivatives.
  770 B (125 words) - 06:59, 14 February 2015
• WIN 55,212-2
  At 5 µM WIN 55,212-2 inhibit ATP production in sperm in a [[CB1]] receptor-dependent fashion. ...nti-inflammatory action is induced through agonist action at [[cannabinoid receptors]], which prevents microglial activation that elicits the inflammation. Addi
  1 KB (190 words) - 07:06, 14 February 2015
• Pravadoline
  ...lammatory and analgesic drug with an IC50 of 4.9 µM and a Ki of 2511nM at CB1, related in structure to non-steroidal antinflammtory drugs (NSAIDs) such a ...y naloxone (1 mg/kg, s.c.) and pravadoline did not bind to the opioid receptors at concentrations up to 10μM
  2 KB (332 words) - 07:15, 14 February 2015
• A-834,735
  ...ing in compounds that still show significant affinity and efficacy at both receptors despite being CB2 selective overall.
  996 B (137 words) - 07:28, 14 February 2015
• AM-1248
  ...ntoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl s
  803 B (106 words) - 07:38, 14 February 2015
• XLR-11 (drug)
  ...d receptors [[CB1]] and [[CB2]] with a Ki of 24.2nM and a EC50 of 359nM at CB1. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to co
  1 KB (216 words) - 07:46, 14 February 2015