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• Cannabinoid
  ...abinoids are a class of diverse chemical compounds that act on cannabinoid receptors on cells that repress neurotransmitter release in the brain. Ligands for th '''Cannabinoid receptors'''
  20 KB (2,948 words) - 14:51, 27 January 2015
• Tetrahydrocannabinol
  ...c activity, THC appears to result in greater downregulation of cannabinoid receptors than endocannabinoids, further limiting its efficacy over other cannabinoid ...thus reducing the effects of anandamide and THC agonism on the CB1 and CB2 receptors.
  23 KB (3,443 words) - 11:33, 6 May 2015
• Cannabinol
  ...as a weak agonist of [[CB1 receptors]] but has a higher affinity to [[CB2 receptors]], with lower affinities in comparison to THC. Because it is a somewhat selective CB2 receptor agonist, it is used experimentally as an immunosuppressant, which
  1 KB (182 words) - 11:44, 6 May 2015
• JWH-164
  ...the[[ CB1]] and [[CB2 receptor]]s, with a Ki of 6.6nM at CB1 and 6.9nM at CB2. JWH-164 is a positional isomer of the related compound [[JWH-081]], but wi
  608 B (93 words) - 07:23, 16 February 2015
• JWH-359
  ...h a chiral side chain which has made it useful in mapping the shape of the CB2 binding site.] It was discovered by, and named after, Dr. [[John W. Huffman
  452 B (75 words) - 07:28, 16 February 2015
• GW-405,833
  ...owed by ataxia and analgesic effects when the dose is increased. Selective CB2 agonist drugs such as GW-405,833 are hoped to be particularly useful in the
  583 B (89 words) - 07:37, 16 February 2015
• Cannabidiol
  ...lower affinities in comparison to THC. Because it is a somewhat selective CB2 receptor agonist, it is used experimentally as an immunosuppressant.
  1,009 B (156 words) - 12:06, 23 February 2015
• Abnormal cannabidiol
  ...GPR55.Further research suggests there are yet more additional cannabinoid receptors.
  1 KB (156 words) - 10:18, 23 February 2015
• Endocannabinoid system
  The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes incl ...s "[[endocannabinoids]]" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids.
  25 KB (3,551 words) - 16:53, 23 February 2015
• Effects of cannabis
  '''Cannabinoids and cannabinoid receptors''' ...honuclear neutrophil cells, T8 cells, and T4 cells. In the tonsils the CB2 receptors appear to be restricted to B-lymphocyte-enriched areas.
  34 KB (5,037 words) - 16:49, 23 February 2015
• Cannabis(drug)
  ...appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose d ...nd delta opioid receptors. THC also potentiates the effects of the glycine receptors. The role of these interactions in the "marijuana high" remains elusive.
  33 KB (5,074 words) - 18:47, 29 January 2015
• Endocannabinoid
  ...s are substances produced from within the body that activate [[cannabinoid receptors]]. After the discovery of the first cannabinoid receptor in 1988, scientist ...entral ([[CB1]]) and, to a lesser extent, peripheral ([[CB2]]) cannabinoid receptors, where it acts as a partial agonist. Anandamide is about as potent as [[THC
  6 KB (886 words) - 16:52, 23 February 2015
• Cannabinoid receptor type 1
  ...nly be stable enough to exist in vivo. Recent evidence suggests that these receptors may also possess an allosteric binding site, which may become a target for ...ion grows more pronounced when considered with the effect of activated CB1 receptors to limit calcium entry into the cell, which does not occur through cAMP but
  20 KB (2,778 words) - 12:11, 23 February 2015
• CB2 receptor
  ...nnabinoids (natural cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG). CB2 was cloned in 1993 by a research group from Cambridge looking for a second
  11 KB (1,531 words) - 11:55, 23 February 2015
• Cannabinoid receptor antagonist
  ...t. This fact led to the logical extension that blocking of the cannabinoid receptors might be useful in decreasing appetite and food intake. It was then discove The endogenous cannabinoid system includes [[cannabinoid receptors]], their endogenous ligands (endocannabinoids) and enzymes for their synthe
  16 KB (2,402 words) - 12:09, 23 February 2015
• JWH-073
  ...B1 subtype, with affinity at this subtype approximately 5x the affinity at CB2. The abbreviation JWH stands for John W. Huffman, one of the inventors of t ...found outside the brain, mostly in the immune system. The binding with CB2 receptors has been shown to be similar between JWH-073 and THC.
  2 KB (386 words) - 03:35, 15 February 2015
• JWH-081
  ...B1 subtype, its affinity at this subtype approximately 10x the affinity at CB2. It was discovered by and named after Dr. John W. Huffman.
  413 B (65 words) - 03:37, 15 February 2015
• JWH-019
  ...ds, and may be useful in characterising the active site of the CB1 and CB2 receptors.
  1 KB (212 words) - 03:42, 15 February 2015
• JWH-007
  ...CB2, and JWH-007 displayed optimum binding of 9.50nM at CB1 and 2.94nM at CB2.
  1 KB (220 words) - 03:46, 15 February 2015
• JWH-015
  ...as [[JWH-133]]. It has been shown to possess immunomodulatory effects, and CB2 agonists may be useful in the treatment of pain and inflammation. It was di
  1 KB (202 words) - 03:48, 15 February 2015
• JWH-133
  ...st, with a Ki of 3.4nM and selectivity of around 200x for CB2 over [[CB1]] receptors. It was discovered by, and named after, John W. Huffman. ...antiinflamatory action is induced through agonist action at [[cannabinoid receptors]], which prevents microglial activation that elicits the inflammation. Addi
  1 KB (214 words) - 03:51, 15 February 2015
• KM-233
  ...nding affinity in vitro for both the [[CB1]] and [[CB2 receptor]]s, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal stu
  752 B (118 words) - 03:59, 15 February 2015
• AB-005
  ...e it was reported to have high affinity for both CB1 (Ki = 5.5 nM) and CB2 receptors (Ki = 0.48 nM).[1] AB-005 features groups found in other previously reporte
  1 KB (141 words) - 04:01, 15 February 2015
• JWH-250
  ...th the [[CB1]] and [[CB2 receptor]]s, with a Ki of 11nM at CB1 and 33nM at CB2. Unlike many of the older JWH series compounds, this compound does not have
  1 KB (180 words) - 04:15, 15 February 2015
• SDB-006
  ...an EC50 for [[CB1]] activation of 19nM, and 7x selectivity for CB1 over [[CB2]]. It was discovered during research into the related compound [[SDB-001]]
  353 B (53 words) - 04:27, 15 February 2015
• Cannabinoid receptor type 2
  ...nnabinoids (natural cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG). CB2 was cloned in 1993 by a research group from Cambridge looking for a second
  11 KB (1,520 words) - 12:12, 23 February 2015
• Cannabis and memory
  == Cannabinoid receptors == ...noid receptor]] research. With the discovery of the endogenous cannabinoid receptors, some recent scientific literature has focused on the effects of phytocanna
  24 KB (3,496 words) - 12:15, 23 February 2015
• Medical cannabis
  ...chers began to study and better understand how cannabinoids acted on these receptors. THC is associated – more than any other cannabinoid – with most of the ...ent of medical cannabis; it is a nonpsychotropic and how it works on brain receptors is not known. CBD represents up to 40% of extracts of Cannabis sativa. A 20
  26 KB (3,891 words) - 14:16, 23 February 2015
• HU-243
  ...nce agonist HU-210. It is a potent agonist at both the [[CB1]] and [[CB2]] receptors, with a binding affinity of 0.041nM at the CB1 receptor, making it marginal
  435 B (67 words) - 04:26, 13 February 2015
• Canbisol
  ...nding studies to determine the structure and function of the [[cannabinoid receptors]], but has been made illegal in some countries due to its possible abuse po
  580 B (84 words) - 04:29, 13 February 2015
• JWH-018
  ...e [[CB1]] and [[CB2]] [[cannabinoid receptors]], with some selectivity for CB2. It produces effects in animals similar to those of [[THC]], a [[cannabinoi ...annabinoid (CB1) receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural det
  9 KB (1,244 words) - 06:53, 14 February 2015
• AM-630
  ...be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of a large number of related derivatives.
  770 B (125 words) - 06:59, 14 February 2015
• A-834,735
  ...ill show significant affinity and efficacy at both receptors despite being CB2 selective overall.
  996 B (137 words) - 07:28, 14 February 2015
• AM-1248
  ...abinoid]] ligands, with an adamantoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when a
  803 B (106 words) - 07:38, 14 February 2015
• XLR-11 (drug)
  ...that acts as a potent agonist for the cannabinoid receptors [[CB1]] and [[CB2]] with a Ki of 24.2nM and a EC50 of 359nM at CB1. It is a 3-(tetramethylcyc
  1 KB (216 words) - 07:46, 14 February 2015
• AB-001
  ...-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimet
  1 KB (153 words) - 07:52, 14 February 2015
• AM-2233
  ...ntiomer. It was developed as a selective radioligand for the [[cannabinoid receptors]] and has been used as its 131I derivative for mapping the distribution of
  623 B (95 words) - 17:21, 14 February 2015
• SR-144,528
  ...ansferase, an effect that appears to be independent from its action on CB2 receptors.
  695 B (111 words) - 16:36, 14 February 2015
• AB-FUBINACA
  ...annabinoid receptors]], with Ki values of 0.9nM at [[CB1]] and 23.2nM at[[ CB2]]. It was originally developed by Pfizer in 2009 as an analgesic medication
  700 B (96 words) - 16:44, 14 February 2015
• N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide
  ...h the usual trend of 2-methyl derivatives having increased selectivity for CB2 (cf. [[JWH-018]] vs [[JWH-007]], [[JWH-081]] vs [[JWH-098]]).
  1 KB (181 words) - 04:25, 14 April 2015
• Cannabipiperidiethanone
  ...receptor]]s and it was found to have an IC50 of 591nM at CB1 and 968nM at CB2, making it 2.3x and 9.4x weaker than [[JWH-250]] at these two targets respe
  565 B (81 words) - 17:23, 14 February 2015
• AM-679 (cannabinoid)
  ...ding the potent CB1 agonists [[AM-694]] and [[AM-2233]], and the selective CB2 agonist [[AM-1241]]. AM-679 was first identified as having been sold as a c
  807 B (122 words) - 17:27, 14 February 2015
• AM-694
  ...1]]. It is used in scientific research for mapping the distribution of CB1 receptors. No public data about AM-694 metabolism is known. AM-694 has already emerge ...iolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.
  1 KB (188 words) - 17:30, 14 February 2015
• AM-2201
  ...binoid receptors]]. Affinities are: with a Ki of 1.0nM at CB1 and 2.6nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities.
  2 KB (301 words) - 17:41, 14 February 2015
• JWH-203
  ...ounds, and has the strongest in vitro binding affinity for the cannabinoid receptors of any compound in the phenylacetyl group.
  1 KB (163 words) - 04:38, 14 April 2015
• SDB-001
  ...01 revealed that it acts as a full agonist at [[CB1]] (EC50 = 34 nM) and [[CB2 receptor]]s (EC50 = 29 nM). Furthermore, SDB-001 possesses cannabis-like ef
  1 KB (182 words) - 04:32, 14 April 2015
• AM-2232
  ...[[cannabinoid receptors]], with a Ki of 0.28nM at [[CB1]] and 1.48nM at[[ CB2]].
  259 B (40 words) - 02:48, 15 February 2015
• O-1057
  ...CB1]] and [[CB2 receptors]], with Ki values of 8.36nM at CB1 and 7.95nM at CB2.
  425 B (61 words) - 02:50, 15 February 2015
• O-2694
  ...[[CB1]] and [[CB2 receptor]]s, with Ki values of 3.7nM at CB1 and 2.8nM at CB2. However, it has complex pharmacokinetics as most of the administered dose
  692 B (106 words) - 02:56, 15 February 2015
• O-2545
  ...[CB1]] and [[CB2 receptor]]s, with Ki values of 1.5nM at CB1 and 0.32nM at CB2.
  394 B (60 words) - 02:58, 15 February 2015