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AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.