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Create the page "CB1 receptors" on this wiki! See also the search results found.

• Cannabinoid
  ...abinoids are a class of diverse chemical compounds that act on cannabinoid receptors on cells that repress neurotransmitter release in the brain. Ligands for th '''Cannabinoid receptors'''
  20 KB (2,948 words) - 14:51, 27 January 2015
• Tetrahydrocannabinol
  ...c activity, THC appears to result in greater downregulation of cannabinoid receptors than endocannabinoids, further limiting its efficacy over other cannabinoid ...jects is believed to result from activity in the gastro-hypothalamic axis. CB1 activity in the hunger centers in the hypothalamus increases the palatabili
  23 KB (3,443 words) - 11:33, 6 May 2015
• Cannabinol
  ...as a weak agonist of [[CB1 receptors]] but has a higher affinity to [[CB2 receptors]], with lower affinities in comparison to THC.
  1 KB (182 words) - 11:44, 6 May 2015
• JWH-164
  ...qual affinity for the[[ CB1]] and [[CB2 receptor]]s, with a Ki of 6.6nM at CB1 and 6.9nM at CB2. JWH-164 is a positional isomer of the related compound [[
  608 B (93 words) - 07:23, 16 February 2015
• JWH-359
  ...t, with a Ki of 13.0nM and selectivity of around 220x for CB2 over [[CB1]] receptors. It is related to other dibenzopyran CB2 agonists such as [[JWH-133]] and[[
  452 B (75 words) - 07:28, 16 February 2015
• GW-405,833
  ...ith an EC50 of 0.65nM and selectivity of around 1200x for CB2 over [[CB1]] receptors. Animal studies have shown it to possess antiinflammatory and anti-hyperalg
  583 B (89 words) - 07:37, 16 February 2015
• Cannabidiol
  ...N acts as a weak agonist of CB1 receptors but has a higher affinity to CB2 receptors, with lower affinities in comparison to THC. Because it is a somewhat selec
  1,009 B (156 words) - 12:06, 23 February 2015
• Abnormal cannabidiol
  ...GPR55.Further research suggests there are yet more additional cannabinoid receptors.
  1 KB (156 words) - 10:18, 23 February 2015
• Endocannabinoid system
  The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes incl ...s "[[endocannabinoids]]" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids.
  25 KB (3,551 words) - 16:53, 23 February 2015
• Effects of cannabis
  '''Cannabinoids and cannabinoid receptors''' ...honuclear neutrophil cells, T8 cells, and T4 cells. In the tonsils the CB2 receptors appear to be restricted to B-lymphocyte-enriched areas.
  34 KB (5,037 words) - 16:49, 23 February 2015
• Cannabis(drug)
  ...g metabolic syndrome risk factors. However, due to the dysphoric effect of CB1 antagonists, this drug is often discontinued due to these side effects. ...nd delta opioid receptors. THC also potentiates the effects of the glycine receptors. The role of these interactions in the "marijuana high" remains elusive.
  33 KB (5,074 words) - 18:47, 29 January 2015
• Cannabis drug testing
  ...y" via activation of neuronal [[cannabinoid]] receptors belonging to the [[CB1]] subtype.
  8 KB (1,224 words) - 12:55, 23 February 2015
• Endocannabinoid
  ...s are substances produced from within the body that activate [[cannabinoid receptors]]. After the discovery of the first cannabinoid receptor in 1988, scientist ...acts as a partial agonist. Anandamide is about as potent as [[THC]] at the CB1 receptor. Anandamide is found in nearly all tissues in a wide range of anim
  6 KB (886 words) - 16:52, 23 February 2015
• Cannabinoid receptor type 1
  The cannabinoid receptor type 1, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located primarily in the centr ...nly be stable enough to exist in vivo. Recent evidence suggests that these receptors may also possess an allosteric binding site, which may become a target for
  20 KB (2,778 words) - 12:11, 23 February 2015
• CB2 receptor
  ...similarity in amino-acid sequence to the [[cannabinoid receptor type 1]] (CB1) receptor, discovered in 1990. The discovery of this receptor helped provid ...uman CB2 receptor, making it somewhat shorter than the 473-amino-acid-long CB1 receptor.
  11 KB (1,531 words) - 11:55, 23 February 2015
• Cannabinoid receptor antagonist
  ...ists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist. ...CB1 receptor represented a new pharmacological target. The first specific CB1 receptor antagonist / inverse agonist was rimonabant, discovered in 1994.
  16 KB (2,402 words) - 12:09, 23 February 2015
• JWH-073
  ...]] and [[CB2]] [[cannabinoid receptors]]. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5x the affinity at CB2 ...found outside the brain, mostly in the immune system. The binding with CB2 receptors has been shown to be similar between JWH-073 and THC.
  2 KB (386 words) - 03:35, 15 February 2015
• JWH-081
  ...] and [[CB2 receptor]]s. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2
  413 B (65 words) - 03:37, 15 February 2015
• JWH-019
  ...ds, and may be useful in characterising the active site of the CB1 and CB2 receptors.
  1 KB (212 words) - 03:42, 15 February 2015
• JWH-007
  ...CB1 and 2.94nM at CB2, and JWH-007 displayed optimum binding of 9.50nM at CB1 and 2.94nM at CB2.
  1 KB (220 words) - 03:46, 15 February 2015