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• Cannabinoid
  ...abinoids are a class of diverse chemical compounds that act on cannabinoid receptors on cells that repress neurotransmitter release in the brain. Ligands for th '''Cannabinoid receptors'''
  20 KB (2,948 words) - 14:51, 27 January 2015
• Tetrahydrocannabinol
  ...c activity, THC appears to result in greater downregulation of cannabinoid receptors than endocannabinoids, further limiting its efficacy over other cannabinoid ...thus reducing the effects of anandamide and THC agonism on the CB1 and CB2 receptors.
  23 KB (3,443 words) - 11:33, 6 May 2015
• Cannabinol
  ...as a weak agonist of [[CB1 receptors]] but has a higher affinity to [[CB2 receptors]], with lower affinities in comparison to THC. Because it is a somewhat selective CB2 receptor agonist, it is used experimentally as an immunosuppressant, which
  1 KB (182 words) - 11:44, 6 May 2015
• JWH-164
  ...the[[ CB1]] and [[CB2 receptor]]s, with a Ki of 6.6nM at CB1 and 6.9nM at CB2. JWH-164 is a positional isomer of the related compound [[JWH-081]], but wi
  608 B (93 words) - 07:23, 16 February 2015
• JWH-359
  ...h a chiral side chain which has made it useful in mapping the shape of the CB2 binding site.] It was discovered by, and named after, Dr. [[John W. Huffman
  452 B (75 words) - 07:28, 16 February 2015
• GW-405,833
  ...owed by ataxia and analgesic effects when the dose is increased. Selective CB2 agonist drugs such as GW-405,833 are hoped to be particularly useful in the
  583 B (89 words) - 07:37, 16 February 2015
• Cannabidiol
  ...lower affinities in comparison to THC. Because it is a somewhat selective CB2 receptor agonist, it is used experimentally as an immunosuppressant.
  1,009 B (156 words) - 12:06, 23 February 2015
• Abnormal cannabidiol
  ...GPR55.Further research suggests there are yet more additional cannabinoid receptors.
  1 KB (156 words) - 10:18, 23 February 2015
• Endocannabinoid system
  The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes incl ...s "[[endocannabinoids]]" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids.
  25 KB (3,551 words) - 16:53, 23 February 2015
• Effects of cannabis
  '''Cannabinoids and cannabinoid receptors''' ...honuclear neutrophil cells, T8 cells, and T4 cells. In the tonsils the CB2 receptors appear to be restricted to B-lymphocyte-enriched areas.
  34 KB (5,037 words) - 16:49, 23 February 2015
• Cannabis(drug)
  ...appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose d ...nd delta opioid receptors. THC also potentiates the effects of the glycine receptors. The role of these interactions in the "marijuana high" remains elusive.
  33 KB (5,074 words) - 18:47, 29 January 2015
• Endocannabinoid
  ...s are substances produced from within the body that activate [[cannabinoid receptors]]. After the discovery of the first cannabinoid receptor in 1988, scientist ...entral ([[CB1]]) and, to a lesser extent, peripheral ([[CB2]]) cannabinoid receptors, where it acts as a partial agonist. Anandamide is about as potent as [[THC
  6 KB (886 words) - 16:52, 23 February 2015
• Cannabinoid receptor type 1
  ...nly be stable enough to exist in vivo. Recent evidence suggests that these receptors may also possess an allosteric binding site, which may become a target for ...ion grows more pronounced when considered with the effect of activated CB1 receptors to limit calcium entry into the cell, which does not occur through cAMP but
  20 KB (2,778 words) - 12:11, 23 February 2015
• CB2 receptor
  ...nnabinoids (natural cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG). CB2 was cloned in 1993 by a research group from Cambridge looking for a second
  11 KB (1,531 words) - 11:55, 23 February 2015
• Cannabinoid receptor antagonist
  ...t. This fact led to the logical extension that blocking of the cannabinoid receptors might be useful in decreasing appetite and food intake. It was then discove The endogenous cannabinoid system includes [[cannabinoid receptors]], their endogenous ligands (endocannabinoids) and enzymes for their synthe
  16 KB (2,402 words) - 12:09, 23 February 2015
• JWH-073
  ...B1 subtype, with affinity at this subtype approximately 5x the affinity at CB2. The abbreviation JWH stands for John W. Huffman, one of the inventors of t ...found outside the brain, mostly in the immune system. The binding with CB2 receptors has been shown to be similar between JWH-073 and THC.
  2 KB (386 words) - 03:35, 15 February 2015
• JWH-081
  ...B1 subtype, its affinity at this subtype approximately 10x the affinity at CB2. It was discovered by and named after Dr. John W. Huffman.
  413 B (65 words) - 03:37, 15 February 2015
• JWH-019
  ...ds, and may be useful in characterising the active site of the CB1 and CB2 receptors.
  1 KB (212 words) - 03:42, 15 February 2015
• JWH-007
  ...CB2, and JWH-007 displayed optimum binding of 9.50nM at CB1 and 2.94nM at CB2.
  1 KB (220 words) - 03:46, 15 February 2015
• JWH-015
  ...as [[JWH-133]]. It has been shown to possess immunomodulatory effects, and CB2 agonists may be useful in the treatment of pain and inflammation. It was di
  1 KB (202 words) - 03:48, 15 February 2015